• 我的賬戶 7×24小時客服熱線:400-829-7929 語言:
    熱門產品: 人參皂苷Rh2,人參皂苷Rg3,雷公藤甲素,蟲草素,金絲桃素
    產品分類
    在線咨詢
    聯系電話:
    銷售:
    400-829-7929(7*24小時)
    028-82633860
    028-82633397 
    028-
    82633165
    技術服務和產品定制:
    028-82633987
    在線服務:  
    沈帥 點擊這里給我發消息 
    文靜  點擊這里給我發消息
    文獻信息

    Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro

    期刊名:NEUROCHEM INT.
    文獻編號:
    文獻地址: http://www.sciencedirect.com/science/article/pii/S0197018615000856
    發表日期:2015 Aug.

    Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro

    Xiao-Long Hu, Li-Ping Guo, Qi Song, Qiao Zhang, Ying Chen, Jian Wang, Wei-Hong Meng, Qing-Chun Zhao  

    Abstract

    A major cause of cerebral ischemia is overactivation of the N-methyl-D-aspartate receptors (NMDARs). Therefore, NMDAR antagonists are needed for the treatment of cerebral ischemia. In our research, KuB protected the SH-SY5Y cells against NMDA-induced injury,apoptosis, LDH release and MMP loss. In addition, KuB could decrease MDA levels while increasing SOD activity. Meanwhile, KuB decreased NADPH oxidase-mediated ROSproduction, inhibited Ca2+ influx, and increased the Bcl-2/Bax ratio. Furthermore, KuB not only down-regulated expression of the NR2B subunit of NMDAR but also actively modulated expression of the signaling molecules downstream of NR2B, including p-ERK, p-CREB, p-AKT and SAPKs. Finally, docking results showed that KuB had a high affinity for NR2B-containing NMDARs. Therefore, we conclude that KuB protected the SH-SY5Y cells from NMDA-induced injury likely by antagonizing NMDARs and reducing oxidative stress.

     Kukoamine B (>98%) was purchased from Chengdu Biopurify Phytochemicals Ltd. (China).

    相關產品
    在線客服系統
    97色色_日本免费最新高清不卡视频_色欲天天天综合网_欧美综合区自拍亚洲综合图